The laboratory of Clinical Immunology is currently looking for a motivated PhD candidate for a research project on different factors that may contribute to the prevention of asthma.
The laboratory of Clinical Immunology is part of the Department of Microbiology and Immunology (KU Leuven). Our research focuses on the mechanisms underlying chronic inflammatory diseases (rhinitis, sinusitis, asthma) with a special interest in regulation of the mucosal barrier function. The current project is supported by EUFOREA, ‘The European Forum for Research and Education in Allergy and Airway Diseases’.
In this PhD project we will study how proper treatment of upper airway disease may contribute to the prevention of asthma. Previous research in our laboratory has shown that upper and lower airways are linked with each other (‘united airway concept’) via different neuronal mechanisms. In addition, new evidence shows that early intervention at the site of the nose and sinuses may lead to a reduction of asthma prevalence. This translational research project consists of in vitro research with human tissue, in vivo research on murine models of asthma and clinical research.
Given the translational nature of this research project, the likelihood of success to obtain a FWO fellowship is high.
- You have a MD or Master in Biomedical Sciences
- You are have a passion for science and motivated to start a PhD
- You are creative, takes initiative and can work independently
For this research project the candidate applies for a FWO fellowship with the help of the host laboratory. The candidate will be supported by the team of Prof Peter Hellings.
Prof. Dr. Peter Hellings is promotor of the project. For more information, please contact Dr. Sven Seys, Mobile: +32 16 342667, Email:
You can apply for this position no later than September 30, 2017.
The laboratory of Clinical Immunology at the KU Leuven, Belgium is accepting applications by highly motivated candidates who want to perform research in another European country.
The research group of Prof. Dr. Peter Hellings is renowned in the field of chronic airway diseases, such as rhinitis, sinusitis and asthma. Currently, we are exploring the regulation of epithelial barrier function and its contribution to pathophysiology, severity and chronicity of both upper and lower airway diseases.
Our group has a major interest in the interaction between inflammation and mucosal barrier function. We identified that a defective epithelial barrier is part of the pathophysiology of allergic rhinitis, which could be restored by intranasal steroids.
More recently, we found that histamine during the early allergic response and T(h)2 cytokines during the delayed allergic immune response both impair epithelial barrier function in allergic rhinitis.
Hence, a research fellow will participate in running research venues evaluating epithelial barrier function in different upper airway diseases and how it contributes to chronicity and severity of disease. Potential candidates will be exposed to a wide range of techniques, going from basic preclinical research to in vivo animal studies.
We seek highly motivated and excellent candidates graduated in biomedical, medical or pharmaceutical sciences with an interest in immunology and the regulation of mucosal barrier homeostasis.
We offer a research stay in a very stimulating environment with excellent training and supervision.
We accept applications until beginning of December 2017.
For more information please contact Dr. Brecht Steelant, tel +3216346165, mail:. Candidates must submit their CV and a motivation letter to Brecht Steelant.