EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialities dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper, a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodelling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize the standard of care of patients with CRSwNP in the future.
Authors: Wytske Fokkens, Eugenio De Corso, Vibeke Backer, Manuel Bernal-Sprekelsen, Leif Bjermer, Christian von Buchwald, Adam Chaker, Zuzana Diamant, Philippe Gevaert, Joseph Han, Claire Hopkins, Valerie Hox, Ludger Klimek, Valerie Lund, Stella Lee, Amber Luong, Joaquim Mullol, Anju Peters, Oliver Pfaar, Sietze Reitsma, Sanna Toppila-Salmi, Guy Scadding, Ahmad Sedaghat, An-Sofie Viskens, Martin Wagenmann, Peter Hellings
